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Schisandra is a very important astringing herb in TCM, used primarily to inhibit the leakage of Lung qi (i.e., to stop cough and wheeze), particularly in the case of chronic coughs

In the case of deficiency of these enzymes (due to gene polymorphisms, or acquired by events such as viral infections, as in HIV infection), these accumulated arene-oxide intermediates act as haptens, stimulating the immune response or binding to tissue macromolecules and causing direct cell damage

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